Some phosphate esters of biological importance

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Title: Some phosphate esters of biological importance
Creator: Tidd BK
Contributor: PUSTAKA2|PUSTAKA2
Subject: TARRC
Date: 20050715 | 20050715 | | 1971 | | | | | | |
Description: Prediction of an approximate phosphate migration rate for compound (III) from data in the literature ^^ gives an expected rate-constant for this compound at 100 aC in O-lN-perchloiic acid of 1*22 × 10“‘ s~l. This is some 200 times slower than the measured hydrolysis rate (20-3 X 10* s’1) for compound (III). The conclusion from these results, that Scheme 1 does not represent the hydrolysis mechanism, is reinforced by the “O incorporation data given in Table 3. Any mechanism proceeding via a phosphate migration followed by C-O bond heterolysis would result in the liberation of orthophosphate containing one more “O atom than the orthophosphate moiety in the unhydrolysed ester. The minimum rate of 19O incorporation into the phosphate moiety of compound (III) at pH I must be comparable with the hydrolysis rate of ca. 20 × 10”* s~l, a value which -is considerably greater than the observed (1-4 × UV* s”1) of incorporation of l*0 into phosphwric add -at the same pR,

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Tidd BK. Some phosphate esters of biological importance. 20050715 | 20050715 | | 1971 | | | | | | |.

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