Metabolic flux analysis in plants: coping with complexity

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Metabolic flux analysis in plants: coping with complexity

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Title: Metabolic flux analysis in plants: coping with complexity
Creator: Allen, D.K.
Creator: Libourel, I.G.L.
Creator: Shachar-Hill, Y.
Contributor: Norzawati Ismail
Contributor: Fauziah A. Rahman
Subject: Document Delivery
Subject: Others
Subject: Pl. Cell & Environ.
Subject: Plant propagation and growth
Date: 7/05/2010 |7/05/2010 |2001– |2009 | | | | | | |
Description: Theory and experience in metabolic engineering both show that metabolism operates at the network level. In plants, this complexity is compounded by a high degree of compartmentation and the synthesis of a very wide array of secondary metabolic products. A further challenge to understanding and predicting plant metabolic function is posed by our ignorance about the structure of metabolic networks even hi well-studied systems. Metabolic flux analysis (MFA) provides tools to measure and model the functioning of metabolism, and is making significant contributions to coping with their complexity.This review gives an overview of different MFA approaches, the measurements required to implement them and the information they yield. The application of MFA methods to plant systems is then illustrated by several examples from the recent literature. Next, the challenges that plant metabolism poses for MFA are discussed together with ways that these can be addressed. Lastly, new developments hi MFA are described that can be expected to improve the range and reliability of plant MFA in the coining years.

Identifier: valet-20100507-145413
Identifier: vital1:69434
Language: EN
Relation: 32,9,-,1241,1257
Relation: Pl Cell Environ (2009) 32(9):1241-1257
Rights: No|No
Type: Article
Source: External/Others

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Allen, D.K., , Libourel, I.G.L., , Shachar-Hill, Y., . Metabolic flux analysis in plants: coping with complexity. 7/05/2010 |7/05/2010 |2001– |2009 | | | | | | |.

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